SML0723

ML252

≥98% (HPLC)

• Sinônimo(s): (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
• Fórmula empírica (Notação de Hill): C₂₀H₂₄N₂O
• Número CAS: 1392494-64-2
• Peso molecular: 308.42
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: , light to dark purple
• solubilidade: DMSO: 25 mg/mL, clear
• temperatura de armazenamento: 2-8°C

Descrição

Ações bioquímicas/fisiológicas

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC₅₀ of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1, unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRs, ion channels, and transporters. Potassium channel Kv7.2 has become a new target for Alzheimer′s Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37, EC₅₀ of 170 nM), suggesting an interaction at a critical site for controlling KCNQ2 channel gating.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable