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Merck
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SML0400

Sigma-Aldrich

ML204

≥98% (HPLC)

Sinônimo(s):

4-Methyl-2-(1-piperidinyl)-quinoline

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About This Item

Fórmula empírica (Notação de Hill):
C15H18N2
Número CAS:
5465-86-1
Peso molecular:
226.32
Número MDL:
MFCD00817920
Código UNSPSC:
12352200
ID de substância PubChem:
329825396
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to beige

solubilidade

DMSO: 5 mg/mL at warmed (clear solution)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cc1cc(nc2ccccc12)N3CCCCC3

InChI

1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3

chave InChI

USYRQXDHKXGTCK-UHFFFAOYSA-N

Aplicação

4-methyl-2-(1- piperidinyl)-quinoline (ML204) has been used to attenuate Ewing sarcoma (EWS)-FLI1 activity in TC32 cells. It has also been used to attenuate scratching behavior evoked by α-Me-5HT in mice.

Ações bioquímicas/fisiológicas

ML204 is a potent and selective TRPC4 channel inhibitor.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Peng Sun et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 34(12), 2164-2172 (2017-09-25)
A novel carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) dispersive solid phase extraction (d-SPE) method combined with gas chromatography (GC) with an electron capture detector (ECD) was developed for the determination of seven pyrethroid pesticides in cucumber, spinach, eggplant, tomato and carrot.
Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice
Lee SH, et al.
The Journal of Allergy and Clinical Immunology, 142(4), 1349-1352 (2018)
Stephanie D Jones et al.
Zoology (Jena, Germany), 118(6), 439-445 (2015-08-25)
The phenotype-linked fertility hypothesis proposes that secondary sexual characters (SSCs) advertise a male's fertility to prospective mates. However, findings from empirical studies attempting to test this hypothesis are often ambivalent or even contradictory, and few studies have simultaneously evaluated how
Domingos M S Pereira et al.
Oxidative medicine and cellular longevity, 2018, 4904696-4904696 (2018-07-10)
Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood. Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) in inflammation, but there is no evidence of
Englerin A inhibits EWS-FLI1 DNA binding in Ewing sarcoma cells
Caropreso V, et al.
The Journal of Biological Chemistry, 291(19), 10058-10066 (2016)
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