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SML0069

Sigma-Aldrich

NSC 33994

≥98% (HPLC)

Sinônimo(s):

(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI), 4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}, G6

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About This Item

Fórmula empírica (Notação de Hill):
C28H42N2O2
Número CAS:
82058-16-0
Peso molecular:
438.65
Número MDL:
MFCD20488055
Código UNSPSC:
12352200
ID de substância PubChem:
329825133
NACRES:
NA.77

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to tan

solubilidade

DMSO: ≥25 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCN(CC)Cc1cc(ccc1O)C(\CC)=C(/CC)c2ccc(O)c(CN(CC)CC)c2

InChI

1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+

chave InChI

QFNJFVBKASKGEU-OCEACIFDSA-N

Aplicação

NSC 33994 may be used in Jak2-mediated cell signaling studies.

Ações bioquímicas/fisiológicas

NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.
Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
061M4619V

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BMJ open diabetes research & care, 8(2) (2020-10-30)
The COVID-19 pandemic forced the Italian government to issue extremely restrictive measures on daily activities since 11 March 2020 ('lockdown'), which may have influenced the metabolic control of type 1 diabetes mellitus (T1D). The aims of the study were to
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Veterinary research, 50(1), 84-84 (2019-10-24)
Rotavirus C (RVC) has been detected increasingly in humans and swine in different countries, including the US. It is associated with significant economic losses due to diarrheal disease in nursing piglets. In this study we aimed: (1) to determine the
Elena Eremeeva et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(40), 9560-9576 (2017-05-18)
The ability of various nucleoside triphosphate analogues of deoxyguanosine and deoxycytidine with 7-deazadeoxyadenosine (A
Tetsushi Yoshikawa et al.
Journal of medical virology, 91(6), 1008-1013 (2019-01-29)
The main aims of the present study were to elucidate the systemic group A rotavirus (RVA) infection and to clarify the genetic changes of persistent virus in the X-linked severe combined immunodeficiency (SCID) patient. RotaTeq vaccine (RV5) genotype-specific real-time reverse
Yuehui Wang et al.
Methods (San Diego, Calif.), 173, 32-43 (2019-06-22)
Influx evidences show that red long non-coding RNAs (lncRNAs) play important roles in various critical biological processes, and they afffect the development and progression of various human diseases. Therefore, it is necessary to precisely identify the lncRNA-disease associations. The identification
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