SAB5702444

Anti-Rad50 Antibody, clone 5M2K10, Rabbit Monoclonal

• Sinônimo(s): NBSLD, RAD502, hRad50
• Código UNSPSC: 12352203
• NACRES: NA.46
• clone: 5M2K10, monoclonal
• application: IP; WB
• reatividade de espécies: rat, human, rat
• técnica(s): immunoprecipitation (IP): 1:50 - 1:200; western blot: 1:500 - 1:2000

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• Materiais: colorless
• clone: 5M2K10, monoclonal
• Formulário: liquid
• peso molecular: 154 kDa
• reatividade de espécies: rat, human, rat
• concentração: 0.85 mg/mL
• técnica(s): immunoprecipitation (IP): 1:50 - 1:200; western blot: 1:500 - 1:2000
• cor: colorless
• Isotipo: IgG
• sequência de imunogênio: RCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIV
• nº de adesão UniProt: Q92878
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... RAD50(10111)

Descrição

Descrição geral

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

Imunogênio

A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Rad50 (Q92878).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Aplicação

WB,IP

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1