SAB5701932

Anti-Phospho-SHC1-Y427 antibody produced in rabbit

• Código UNSPSC: 12352203

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: liquid
• reatividade de espécies: mouse, human
• concentração: 2.53 mg/mL
• técnica(s): western blot: 1:500-1:2000
• nº de adesão UniProt: P29353
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pTyr427)
• Informações sobre genes: human ... SHC1(6464)

Descrição

Descrição geral

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Imunogênio

A phospho specific peptide corresponding to residues surrounding Y427 of human SHC1.

forma física

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable