SAB5700429

Anti-Phospho-BCR-Y177 antibody produced in rabbit

• Sinônimo(s): ALL, BCR, BCR1, CML, D22S11, D22S662, PHL
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: 137; 142
• reatividade de espécies: mouse, human
• concentração: 2.66 mg/ml
• técnica(s): western blot: 1:500-1:2000
• nº de adesão UniProt: P11274
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pTyr177)
• Informações sobre genes: human ... BCR(613)

Descrição

Descrição geral

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Imunogênio

A synthetic phosphorylated peptide around Y177 of human BCR (NP_004318.3).

forma física

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Armazenamento e estabilidade

Store at -20℃. Avoid freeze / thaw cycles.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable