SAB4702062

Monoclonal Anti-HLA-E purified produced in mouse

• Sinônimo(s): HLA class I histocompatibility antigen, MHC class I antigen E, alpha chain E
• Código UNSPSC: 12352203

Propriedades

• conjugado: unconjugated
• Nível de qualidade: 100
• tipo de produto de anticorpo: primary antibodies
• clone: MEM-E/02, monoclonal
• Formulário: buffered aqueous solution
• reatividade de espécies: ( Non-human primates), human
• concentração: 1 mg/ml
• técnica(s): immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG1
• nº de adesão UniProt: P13747
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... HLA-E(3133)

Descrição

Descrição geral

HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).

Especificidade

The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.

Imunogênio

Recombinant human HLA-E denaturated heavy chain.

forma física

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparo

Purified by protein-A affinity chromatography.

Armazenamento e estabilidade

Store at 2-8°C. Do not freeze.

Outras notas

The antibody solution should be gently mixed before use.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable