SAB4702032

Monoclonal Anti-CD120a purified low endotoxin produced in mouse

• Sinônimo(s): FPF, TBP1, TNF R1, TNFR55, TNFRSF1A, p60
• Código UNSPSC: 12352203

Propriedades

• conjugado: unconjugated
• Nível de qualidade: 100
• tipo de produto de anticorpo: primary antibodies
• clone: H398, monoclonal
• Formulário: buffered aqueous solution
• reatividade de espécies: human
• concentração: 1 mg/ml
• técnica(s): FUNC: suitable; flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• Isotipo: IgG2a
• nº de adesão UniProt: P19438
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TNFRSF1A(7132)

Descrição

Descrição geral

CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

Especificidade

The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.

Imunogênio

Recombinant full length human CD120a

forma física

Phosphate buffered saline (PBS), pH 7.4

Nota de preparo

Purified by protein-A affinity chromatography.

Armazenamento e estabilidade

Store at 2-8°C. Do not freeze.

Outras notas

The antibody solution should be gently mixed before use.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1