SAB4702025

Monoclonal Anti-EGFR PE produced in mouse

• Sinônimo(s): EGF-R, ERBB1, Her1, NISBD2, PIG61
• Código UNSPSC: 12352203

Propriedades

• conjugado: phycoerythrin (R-PE) conjugate
• Nível de qualidade: 100
• tipo de produto de anticorpo: primary antibodies
• clone: EGFR1, monoclonal
• Formulário: buffered aqueous solution
• reatividade de espécies: horse, ( Human)
• técnica(s): flow cytometry: suitable
• Isotipo: IgG2bκ
• nº de adesão UniProt: P00533
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... EGFR(1956)

Descrição

Descrição geral

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.

Especificidade

The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273.

Imunogênio

Human epidermoid carcinoma line A431

forma física

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparo

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Armazenamento e estabilidade

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Outras notas

The antibody solution should be gently mixed before use.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable