SAB4503840

Anti-phospho-WNK1 (pThr⁵⁸) antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen 250 kDa
• reatividade de espécies: rat, human, mouse
• concentração: ~1 mg/mL
• técnica(s): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• nº de adesão NCBI: Q9H4A3
• nº de adesão UniProt: Q9H4A3
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pThr58)
• Informações sobre genes: human ... WNK1(65125)

Descrição

Descrição geral

The WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The encoded protein belongs to the WNK kinase family and is ubiquitously expressed.

Imunogênio

The antiserum was produced against synthesized peptide derived from human WNK1 around the phosphorylation site of Thr58.

Immunogen Range: 24-73

Ações bioquímicas/fisiológicas

WNK1 (WNK lysine deficient protein kinase 1) is responsible for maintaining the ion homeostasis. It regulates mitogen-activated protein kinase 7 (MAPK7) mediated cell proliferation and migration. It is also known to promote tumor proliferation, invasion and metastasis in prostate carcinoma. WNK1 expression is essential for vascular remodeling and endothelial sprouting. Autophagy has been indicated in various diseases. This intracellular degradation pathway is prevented by WNK1.(3)

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable