SAB4503023

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷) antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): C1 esterase, C1S, Complement C1s subcomponent, Complement component 1 subcomponent s
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen 47 kDa; antigen 76 kDa
• reatividade de espécies: human
• concentração: ~1 mg/mL
• técnica(s): ELISA: 1:20000; western blot: 1:500-1:1000
• nº de adesão NCBI: P09871
• nº de adesão UniProt: P09871
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: proteolytically cleaved (Arg437)
• Informações sobre genes: human ... C1S(716)

Descrição

Descrição geral

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷ Antibody detects endogenous levels of fragment of activated C1S (heavy chain, Cleaved-Arg⁴³⁷protein.

The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.

Imunogênio

The antiserum was produced against synthesized peptide derived from human C1S.

Immunogen Range: 388-437

Ações bioquímicas/fisiológicas

Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated lupus nephritis, with low gene expression observed in mice.

Características e benefícios

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forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable