SAB4500620
Anti-DAPK1 antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
DAP kinase 1, DAPK, Death associated protein kinase, kinase DAPK1
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen 160 kDa
reatividade de espécies
mouse, human
concentração
~1 mg/mL
técnica(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... DAPK1(1612)
Categorias relacionadas
Descrição geral
Anti-DAPK1 Antibody detects endogenous levels of total DAPK1 protein.
Death associated protein kinase 1 (DAPK1) is a calcium/calmodulin–regulated (CaM-regulated) protein kinase that belongs to the kinases family. The protein structure contains a kinase domain, a CaM binding domain, eight ankyrin repeats, and a death domain. DAPK1 protein is encoded by the gene mapped to human chromosome 9q21.33. Anti-DAPK1 antibody detects endogenous levels of total DAPK1 protein.
Imunogênio
The antiserum was produced against synthesized peptide derived from human DAPK1.
Immunogen Range: 274-323
Immunogen Range: 274-323
Aplicação
Anti-DAPK1 antibody produced in rabbit has been used in:
- immunohistochemistry(1:400 )
- coimmunoprecipitation
- immunoblot
Ações bioquímicas/fisiológicas
Death associated protein kinase 1 (DAPK1) acts as a death-inducing factor in response to interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β. It also induces autophagy, proliferation, and immune response to inflammatory signals. DAPK1 promotes the growth of p53-mutant cancers, including pancreatic and ovarian cancers. Therefore, downregulation of DAPK1 can be a potential therapeutic strategy for treating P53 mutant cancers. Overexpression of DAPK1 protein has been observed in Alzheimer′s disease (AD) patients.
Características e benefícios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Não está encontrando o produto certo?
Experimente o nosso Ferramenta de seleção de produtos.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Asia Asiaf et al.
Asian Pacific journal of cancer prevention : APJCP, 20(3), 839-848 (2019-03-27)
Aims: Death-associated protein kinase-1 (DAPK1) is a pro-apoptotic Ser/Thr kinase that participates in cell apoptosis and tumor suppression. DAPK1 is frequently lost in many different tumor types including breast cancer. The aim of this study was to evaluate the promoter
Jing Zhang et al.
Cellular & molecular immunology, 11(3), 245-252 (2014-02-18)
Interferon regulatory factor (IRF) 7 has been demonstrated to be a master regulator of virus-induced type I interferon production (IFN), and it plays a central role in the innate immune response against viruses. Here, we identified death-associated protein kinase 1
Craig Stevens et al.
The Journal of biological chemistry, 284(1), 334-344 (2008-11-01)
Death-associated protein kinase (DAPK) is a multidomain enzyme that plays a central role in autophagic and apoptotic signaling, although the protein-protein interactions regulating DAPK functions are not well defined. Peptide aptamer libraries were used to identify the tumor suppressor protein
Jing Zhao et al.
The Journal of clinical investigation, 125(7), 2707-2720 (2015-06-16)
Estrogen receptor-negative (ER-negative) breast cancers are extremely aggressive and associated with poor prognosis. In particular, effective treatment strategies are limited for patients diagnosed with triple receptor-negative breast cancer (TNBC), which also carries the worst prognosis of all forms of breast
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica