SAB4500378
Anti-Collagen IV α3 (Cleaved-Pro1426) antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
CO4A3, COL4A3, Collagen α-3(IV) chain, Goodpasture antigen, Tumstatin
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen 27 kDa
reatividade de espécies
human
concentração
~1 mg/mL
técnica(s)
ELISA: 1:40000
western blot: 1:500-1:1000
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
proteolytically cleaved (Pro1426)
Informações sobre genes
human ... COL4A3(1285)
Descrição geral
Collagen type IV alpha 3 chain (COL4A3) gene with 52 exons, codes for the α3 chain of type IV collagen. COL4A3 protein is the vital structural protein in the basement membrane. COL4A3 gene is located on human chromosome 2q36.3. Anti-Collagen IV α3 (cleaved-pro1426) antibody detects endogenous levels of fragment of activated collagen IV α3 (cleaved-pro1426) protein.
Imunogênio
The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3.
Immunogen Range: 1407-1456
Immunogen Range: 1407-1456
Ações bioquímicas/fisiológicas
Type IV collagen plays a key role in cell adhesion, proliferation, migration, survival, and differentiation. It maintains the assembly and mechanical stability by acting as a scaffold. Collagen type IV alpha 3 chain (COL4A3) mutations are associated with Alport syndrome (AS). Heterozygous mutations in the COL4A4 gene are observed in individuals with benign familial hematuria (BFH). Alterations in the COL4A3 gene also result in diabetic kidney disease from maturity-onset diabetes.
Características e benefícios
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forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
C Cervera-Acedo et al.
BMC nephrology, 18(1), 325-325 (2017-11-02)
Alport syndrome is an inherited renal disorder characterized by glomerular basement membrane lesions with hematuria, proteinuria and frequent hearing defects and ocular abnormalities. The disease is associated with mutations in genes encoding α3, α4, or α5 chains of type IV
Laurence Heidet et al.
Journal of the American Society of Nephrology : JASN, 12(1), 97-106 (2001-01-03)
Mutations in either the COL4A3 or the COL4A4 genes, encoding the alpha3 and alpha4 chains of type IV collagen, are responsible for the autosomal-recessive form of Alport syndrome, a progressive hematuric nephropathy characterized by glomerular basement membrane abnormalities. Reported here
Liang Xia et al.
Disease markers, 2019, 8705989-8705989 (2019-03-19)
Mutations in the COL4A3 gene are frequently reported to be associated with various types of hereditary nephropathy. COL4A3 encodes the α3 chain of type IV collagen, which is the main structural protein in the basement membrane. Mutations in this gene
Daniel Öhlund et al.
BMC cancer, 13, 154-154 (2013-03-28)
Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resistance. Cancer cells actively take part in the
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