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Key Documents

SAB4200576

Sigma-Aldrich

Anti-COX2 antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen ~75 kDa

reatividade de espécies

human, mouse

validação aprimorada

recombinant expression
Learn more about Antibody Enhanced Validation

concentração

~1.0 mg/mL

técnica(s)

indirect immunofluorescence: 5-10 μg/mL using RAW-264.7 cells stimulated with LPS
western blot: 1.5-3.0 μg/mL using lysates of RAW-264.7 cells stimulated with LPS, and of HEK-293T cells overexpressing human COX2

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... COX2(5743)

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Descrição geral

Cytochrome c oxidase subunit II (COX2) is encoded by the gene mapped to human chromosome 1. The encoded protein is one of the isoforms of COX protein. It is expressed in specific cells such as activated macrophages, monocytes, neutrophils and lymphocytes, in response to inflammatory stimuli such as mitogen, cytokines and growth factors.

Imunogênio

synthetic peptide corresponding to an internal sequence of human COX2 (GeneID: 5743), conjugated to KLH. The corresponding sequence has high homology to rat COX2 (83% identity) and to mouse COX2 (82% identity).

Aplicação

Anti-COX2 antibody produced in rabbit has been used in immunohistochemical staining.

Ações bioquímicas/fisiológicas

Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid (AA) to prostaglandins (PG). Mutation in the gene is associated with the development of gastric cancer. Elevated expression of the gene has been observed in various chronic and autoimmune diseases.

forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer.
Lu X, et al.
Cell Biochemistry and Biophysics, 72(3), 657-660 (2015)
Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors (2012)
Expression of IL-17 and COX2 gene in peripheral blood leukocytes of vitiligo patients.
Esmaeili B, et al.
Iranian Journal of Allergy, Asthma, and Immunology, 10(2), 81-81 (2011)
Immunohistological study of the effect of extravirgin olive oil on aspartame-treated cerebellum of male albino rat
Baky F A F A .
Menoufia Medical Journal, 29(3), 728-728 (2016)
Anna Koumarianou et al.
Anticancer research, 34(9), 4949-4962 (2014-09-10)
Several studies have recently indicated the prognostic or predictive role of several biomarkers in colorectal cancer. We sought to investigate the prognostic value of prostaglandin synthase 2 (PTGS2), cyclooxygenase 2 (COX2), thymidylate synthetase (TYMS), thymidine phosphorylase (TYMP), dihydropyrimidine dehydrogenase (DPYD)

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