SAB4200518

Anti-SLC1A1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinônimo(s): Anti-EAAT3, Anti-solute carrier family 1, member 1, EAAC1
• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: IHC; WB
• clone: polyclonal
• reatividade de espécies: mouse, human
• citations: 2
• técnica(s): immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded human small intestine.; western blot: 1.5-3.0 μg/mL using Neuro-2a cell extracts.

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen ~70 kDa
• reatividade de espécies: mouse, human
• validação aprimorada: recombinant expression; Learn more about Antibody Enhanced Validation
• concentração: ~1.0 mg/mL
• técnica(s): immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded human small intestine.; western blot: 1.5-3.0 μg/mL using Neuro-2a cell extracts.
• nº de adesão UniProt: P43005
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SLC1A1(6505) ; mouse ... Slc1a1(20510) ; rat ... Slc1a1(25550)

Descrição

Descrição geral

SLC1A1 (also known as EAAC1, EAAT3) is localized at the postsynaptic site of neurons. It is expressed at moderate levels in the adult brain, mainly in the hippocampus, basal ganglia and olfactory bulb and is considered to make a minor contribution to glutamate removal from the synapse.

Imunogênio

synthetic peptide corresponding to a sequence near the C-terminus of human SLC1A1, conjugated to KLH. The corresponding sequence is identical in mouse and rat SLC1A1.

Aplicação

Anti-SLC1A1 antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.

Ações bioquímicas/fisiológicas

SLC1A1 regulates the developmental effects of glutamate. It is highly regulated by neural activity and intracellular signaling pathways involving mainly PKCa, PI3K, and glial factors, resulting in rapid changes in the trafficking of the transporter and in its membrane location.

forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable