SAB4200471

Anti-SND1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinônimo(s): Anti-TDRD11, Anti-staphylococcal nuclease and tudor domain containing 1, p100
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: antigen ~102 kDa
• reatividade de espécies: rat, mouse, human
• concentração: ~1.0 mg/mL
• técnica(s): immunoprecipitation (IP): 1-2 μg using lysates of rat NRK cells.; indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa cells; western blot: 0.25-0.5 μg/mL using whole extracts of mouse NIH-3T3 cells.
• nº de adesão UniProt: Q7KZF4
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SND1(27044) ; mouse ... Snd1(56463) ; rat ... Snd1(64635)

Descrição

Descrição geral

Staphylococcal nuclease and tudor domain containing 1 (SND1) protein contains five staphylococcal nuclease-like domains and a tudor-like domain. SND1 is a component of the RNA-induced silencing complex (RISC). This gene is highly conserved from yeast to human.

Imunogênio

peptide corresponding to the C-terminal region of human SND1 (GeneID: 27044), conjugated to KLH. The corresponding sequence is identical in mouse and rat.

Aplicação

Anti-SND1 (C-terminal) antibody produced in rabbit has been used in immunoblotting, immunoprecipitation and immunofluorescence.

Ações bioquímicas/fisiológicas

Staphylococcal nuclease and tudor domain containing 1 (SND1) has been shown to be involved in the regulation of transcription and RNA biogenesis. It is known to interact with nucleic acids and proteins. SND1 promotes the breakdown of hyper-edited inosine-containing miRNA precursors. It modulates miRNA transcription and translation through RNA editing by ADAR (adenosine deaminase acting on RNA). Increased SND1 expression is seen in human colon cancer tissues and cell lines.

forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable