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SAB3500082

Sigma-Aldrich

Anti-NOTUM antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Anti-NOTUM pectinacetylesterase homolog

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

reatividade de espécies

human, rat, mouse

técnica(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... NOTUM(147111)

Descrição geral

NOTUM encodes palmitoleoyl-protein carboxylesterase. In human chromosome, the gene NOTUM is localized on 17q25.3.

Imunogênio

NOTUM antibody was raised against a 19 amino acid peptide near the amino terminus of human NOTUM.

Aplicação

Anti-NOTUM antibody produced in rabbit has been used in immunostaining.

Ações bioquímicas/fisiológicas

Notum is involved in the progression of colorectal cancer and its expression levels is higher in metastatic cells. Notum is one of the pain associated genes.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by β-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.

Ligação

The action of this antibody can be blocked using blocking peptide SBP3500082.

forma física

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Nº do produto
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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Transcriptional dynamics of cultured human villous cytotrophoblasts
Robinson JF, et al.
Endocrinology, 158(6), 1581-1594 (2017)
NOTUM Is Involved in the Progression of Colorectal Cancer
Yoon JH, et al.
Cancer, Genomics, and Proteomics, 15(6), 485-497 (2018)
Tianyanxin Sun et al.
The Journal of clinical endocrinology and metabolism, 105(12) (2020-08-11)
Crosstalk through receptor ligand interactions at the maternal-fetal interface is impacted by fetal sex. This affects placentation in the first trimester and differences in outcomes. Sexually dimorphic signaling at early stages of placentation are not defined. Investigate the impact of
Laura Mannarino et al.
Cell death & disease, 13(7), 612-612 (2022-07-16)
Although clinical antitumor activity of Tumor Treating Fields (TTFields) has been reported in malignant pleural mesothelioma (MPM) patients, the mechanisms behind the different selectivity displayed by the various MPM histotypes to this physical therapy has not been elucidated yet. Taking
Establishment of a murine pancreatic cancer pain model and microarray analysis of pain-associated genes in the spinal cord dorsal horn
Wang L, et al.
Molecular Medicine Reports, 16(4), 4429-4436 (2017)

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