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SAB2100069

Sigma-Aldrich

Anti-AFF3 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Anti-AF4/FMR2 family, member 3, Anti-LAF4, Anti-MLLT2-like

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

133 kDa

reatividade de espécies

human

concentração

0.5 mg - 1 mg/mL

técnica(s)

western blot: suitable

nº de adesão UniProt

P51826

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... AFF3(3899)

Descrição geral

AF4/FMR2 family member 3 (AFF3), a tissue-restricted nuclear transcriptional activator, is mainly expressed in the lymphoid tissue. This RNA binding protein is a member of the AF4/LAF4/FMR2/AF5q31 family. AFF3 is a component of the transcriptional super elongation complex. It is expressed at a high level in the thymus. AFF3 has two domains with transactivation activity. This lymphoid-specific gene, is located on the human chromosome 2q11.2.

Imunogênio

Synthetic peptide directed towards the middle region of human AFF3

Ações bioquímicas/fisiológicas

AF4/FMR2 family member 3 (AFF3) participates in transcriptional regulation. It is a potential clinical modulator of estrogen receptor (ER) signaling. This transcription activator can play a role in lymphoid development and cancer. It can bind to double-stranded DNA in vitro. AFF3 overexpression causes tamoxifen resistance and estrogen-independent proliferation in ER+ human breast tumors.

Sequência

Synthetic peptide located within the following region: APATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD

forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Yawei Shi et al.
Journal of experimental & clinical cancer research : CR, 37(1), 254-254 (2018-10-18)
Although tamoxifen is a highly effective drug for treating estrogen receptor-positive (ER+) breast cancer, nearly all patients with metastasis with initially responsive tumors eventually relapse, and die from acquired drug resistance. Unfortunately, few molecular mediators of tamoxifen resistance have been
Norine Voisin et al.
American journal of human genetics, 108(5), 857-873 (2021-05-08)
The ALF transcription factor paralogs, AFF1, AFF2, AFF3, and AFF4, are components of the transcriptional super elongation complex that regulates expression of genes involved in neurogenesis and development. We describe an autosomal dominant disorder associated with de novo missense variants

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