S6949

β-Synuclein V70M histidine-tagged human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

• Sinônimo(s): SNCB
• Número MDL: MFCD08705537
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• recombinante: expressed in E. coli
• Nível de qualidade: 200
• Ensaio: ≥90% (SDS-PAGE)
• Formulário: lyophilized powder
• nº de adesão UniProt: Q16143
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... SNCB(6620)

Descrição

Ações bioquímicas/fisiológicas

Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missense mutations in neurodegeneration stimulation.

forma física

Lyophilized from a 0.2 μm filtered solution.

Reconstituição

Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at −20 °C.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)