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R1031

Sigma-Aldrich

RSK1, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinônimo(s):

HU-1, MAPKAPK1A, RPS6KA1, S6K-alpha 1

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.32

recombinante

expressed in baculovirus infected Sf9 cells

Nível de qualidade

200

linha de produto

PRECISIO® Kinase

Ensaio

≥70% (SDS-PAGE)

forma

buffered aqueous glycerol solution

atividade específica

159-215 nmol/min·mg

peso molecular

~108 kDa

nº de adesão UniProt

Q15418

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... RPS6KA1(6195)

Descrição geral

Ribosomal protein S6 kinase α-1 (RPS6KA1) or RSK1 is a member of the RSK (ribosomal S6 kinase) family that consists of growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue.

Ações bioquímicas/fisiológicas

Ribosomal S6 kinases (RSKs) are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation. The protein suppresses the pro-apoptotic function of BAD by phosphorylating it. RSK1 phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway.

forma física

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Informações legais

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Rsk1 mediates a MEK-MAP kinase cell survival signal.
Shimamura A
Current Biology (2000)
Jingfeng Zhang et al.
Nucleic acids research, 48(16), 9361-9371 (2020-07-28)
Human Y-box binding protein 1 (YB-1) is a multifunctional protein and overexpressed in many types of cancer. It specifically recognizes DNA/RNA through a cold shock domain (CSD) and regulates nucleic acid metabolism. The C-terminal extension of CSD and the phosphorylation
S D Gross et al.
Science (New York, N.Y.), 286(5443), 1365-1367 (1999-11-13)
Before fertilization, vertebrate eggs are arrested in metaphase of meiosis II by cytostatic factor (CSF), an activity that requires activation of the mitogen-activated protein kinase (MAPK) pathway. To investigate whether CSF arrest is mediated by the protein kinase p90Rsk, which
D E Moller et al.
The American journal of physiology, 266(2 Pt 1), C351-C359 (1994-02-01)
Serine-threonine protein kinases in the ribosomal S6 kinase (rsk or p90rsk) family have been implicated as signaling intermediates in the cellular response to several growth factors. To investigate the molecular diversity of human p90rsk isoforms, mixed degenerate oligonucleotide polymerase chain

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