R102-05N
Rat Epidermal Keratinocytes: REK, neonatal
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About This Item
Código UNSPSC:
41106514
NACRES:
NA.81
Produtos recomendados
fonte biológica
rat skin (Sprague Dawley)
Nível de qualidade
embalagem
pkg of 500,000 cells
fabricante/nome comercial
Cell Applications, Inc
modo de crescimento
Adherent
morfologia
Epidermal
técnica(s)
cell culture | mammalian: suitable
doença(s) relevante(s)
allergies; cancer
Condições de expedição
dry ice
temperatura de armazenamento
−196°C
Descrição geral
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REK from Cell Applications, Inc. provide a suitable model system to study many aspects of epithelial function and disease, particularly those related to skin biology and toxicology. It was shown that TGFβ1 treatment decreased c-Myc mRNA in REK which, taken together with the TGFβ1-induced growth arrest exhibited by keratinocytes and opposite results obtained in other cells, suggests a correlation between c-Myc mRNA expression and the mitogenic response (Nakai, 2008). Additionally, REK were used to demonstrate that pathological increases in keratinocyte sodium channels Nav1.1, Nav1.6, and Nav1.8 expression may contribute to pain by increasing epidermal ATP release, resulting in excessive activation of P2X receptors on primary sensory axons (Zhao, 2008). REK were also used to demonstrate that laminin 332 deposition is inhibited by ionizing radiation and, in combination with slower keratinocyte migration, can contribute to the delayed wound healing of irradiated skin (Jourdan, 2011).
REK from Cell Applications, Inc. provide a suitable model system to study many aspects of epithelial function and disease, particularly those related to skin biology and toxicology. It was shown that TGFβ1 treatment decreased c-Myc mRNA in REK which, taken together with the TGFβ1-induced growth arrest exhibited by keratinocytes and opposite results obtained in other cells, suggests a correlation between c-Myc mRNA expression and the mitogenic response (Nakai, 2008). Additionally, REK were used to demonstrate that pathological increases in keratinocyte sodium channels Nav1.1, Nav1.6, and Nav1.8 expression may contribute to pain by increasing epidermal ATP release, resulting in excessive activation of P2X receptors on primary sensory axons (Zhao, 2008). REK were also used to demonstrate that laminin 332 deposition is inhibited by ionizing radiation and, in combination with slower keratinocyte migration, can contribute to the delayed wound healing of irradiated skin (Jourdan, 2011).
Origem de linhagem celular
Skin
Aplicação
Skin biology and toxicology, wound healing, artificial skin, cell proliferation, migration, UV light response.
Componentes
Rat Keratinocyte Basal Medium that contains 10% FBS and 10% DMSO
Qualidade
Each lot was tested for proper morphology, Population Doublings, Negative for HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi.
Nota de preparo
- Primary culture, >500,000 cells in Rat Keratinocyte Basal Medium that contains 10% FBS and 10% DMSO
- These epithelial cells proliferate well when thawed and plated from cryopreservation, but they do not plate and proliferate after trypsinization
Rotina de subcultura
Please refer to the RDF Culture Protocol.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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