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Documentos Principais

PLA0057

Sigma-Aldrich

Rabbit anti-Mre11 Antibody, Affinity Purified

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Sinônimo(s):

AT-like disease, ATLD, DNA recombination and repair protein, HNGS1, MRE11, MRE11 double strand break repair nuclease A, MRE11 homolog, MRE11 homolog 1, MRE11 homolog A, MRE11 meiotic recombination 11 homolog A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11 meiotic recombination 11-like protein A, MRE11B, double strand break repair nuclease A, endo/exonuclease Mre11, meiotic recombination (S. cerevisiae) 11 homolog A, meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

grau

Powered by Bethyl Laboratories, Inc.

reatividade de espécies

human

técnica(s)

immunohistochemistry: 1:1,000-1:5,000
western blot: 1:1,000- 1:5,000

nº de adesão

NP_005582.1

nº de adesão UniProt

P49959

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

rabbit ... Mre11(4361)

Imunogênio

The epitope recognized by PLA0057 maps to a region between residues 1 and 50 of human Meiotic Recombination 11 homolog A using the numbering given in entry NP_005582.1 (GeneID 4361).

forma física

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Outras notas

Mre11 is a component of the MRN complex and plays a role in telomere maintenance and double-strand break (DSB) repair. Mre11 associates with rad50 in the MRN complex. Mre11 possesses 3′– 5′ exonuclease activity that is involved in creating DNA termini in DSB suitable for priming DNA synthesis and ligation.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Mariko Tsukagoshi et al.
Oncotarget, 8(26), 42159-42172 (2017-02-09)
Cholangiocarcinoma is a highly malignant tumor, and the development of new therapeutic strategies is critical. Karyopherin-α2 (KPNA2) functions as an adaptor that mediates nucleocytoplasmic transport. Specifically, KPNA2 transports one of the important DNA repair machineries, the MRE11-RAD50-NBS1 (MRN) complex, to
Beeke Wienert et al.
Science (New York, N.Y.), 364(6437), 286-289 (2019-04-20)
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct detection in vivo. We developed DISCOVER-Seq (discovery of in situ
Rebecca M Martin et al.
Oncotarget, 5(4), 993-1003 (2014-03-15)
Predictive assays are needed to help optimise treatment in muscle-invasive bladder cancer, where patients can be treated by either cystectomy or radical radiotherapy. Our finding that low tumour MRE11 expression is predictive of poor response to radiotherapy but not cystectomy
Bárbara Alcaraz Silva et al.
The Journal of biological chemistry, 289(33), 22771-22784 (2014-07-02)
Chromosome ends contain nucleoprotein structures known as telomeres. Damage to chromosome ends during interphase elicits a DNA damage response (DDR) resulting in cell cycle arrest. However, little is known regarding the signaling from damaged chromosome ends (designated here as "TIPs")

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