PLA0030

Rabbit anti-TopBP1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Sinônimo(s): DNA topoisomerase II-beta-binding protein 1, DNA topoisomerase II-binding protein 1, KIAA0259, TOP2BP1, TopBP1
• Código UNSPSC: 12352203
• NACRES: NA.43
• reatividade de espécies: mouse, human
• application: IP; WB
• técnica(s): immunoprecipitation (IP): 2-5 μg/mg; western blot: 1:2,000-1:10,000
• citations: 2

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• grau: Powered by Bethyl Laboratories, Inc.
• reatividade de espécies: mouse, human
• técnica(s): immunoprecipitation (IP): 2-5 μg/mg; western blot: 1:2,000-1:10,000
• nº de adesão: NP_008958.1
• nº de adesão UniProt: Q92547
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: rabbit ... TopBP1(11073)

Descrição

Imunogênio

The epitope recognized by PLA0030 maps to a region between residue 1400 and the C-terminus (residue 1435) of human Topoisomerase (DNA) II Binding Protein 1 using the numbering given in entry NP_008958.1 (GeneID 11073).

forma física

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Outras notas

Topoisomerases regulate topological states of DNA. DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable