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Merck
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Key Documents

P9607

Sigma-Aldrich

Anti-Potassium Channel Kv2.1 (DRK1) antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

IgG fraction of antiserum

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

lyophilized powder

reatividade de espécies

rat

técnica(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:250-1:500

nº de adesão UniProt

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... KCNB1(3745)
mouse ... Kcnb1(16500)
rat ... Kcnb1(25736)

Imunogênio

synthetic peptide corresponding to amino acids 837-853 of rat potassium channel Kv2.1 (with an additional N-terminal cysteine and tyrosine).The epitope is identical in mouse and rat and highly homologous in human and pig.

forma física

Lyophilized at ∼1 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.05% sodium azide.

Nota de preparo

Protein A purified.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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J S Trimmer
Proceedings of the National Academy of Sciences of the United States of America, 88(23), 10764-10768 (1991-12-01)
Antibodies specific for the drk1 polypeptide were used to characterize the corresponding protein in rat brain. Recombinant and synthetic immunogens containing fragments of the drk1 polypeptide were produced. Antibodies raised to these immunogens display monospecific reactions with the same 130-kDa
G Shi et al.
The Journal of biological chemistry, 269(37), 23204-23211 (1994-09-16)
We have transiently expressed the rat Kv2.1 K+ channel polypeptide (pKv2.1) at high levels by transfection of mammalian COS-1 cells. Kv2.1-transfected cells express a molecular mass of 108 kDa pKv2.1, larger than the size of the core polypeptide (95 kDa)
G C Frech et al.
Nature, 340(6235), 642-645 (1989-08-24)
Voltage-activated potassium channels play an important part in the control of excitability in nerve and muscle. Different K+ channels are involved in establishing the resting potential, determining the duration of action potentials, modulation of transmitter release, and in rhythmic firing
P M Hwang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(4), 1569-1576 (1993-04-01)
We have localized CDRK and DRK1, two novel K+ channels of the Shab subfamily by immunohistochemistry. The two channels are closely related in structure with about 90% amino acid identity in the N-terminal and middle portions and 60% identity in
Marjaana A Peltola et al.
EMBO reports, 12(12), 1293-1299 (2011-11-08)
Kv2.1 is a potassium channel α-subunit abundantly expressed throughout the brain. It is a main component of delayed rectifier current (I(K)) in several neuronal types and a regulator of excitability during high-frequency firing. Here we identify AMIGO (amphoterin-induced gene and

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