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Documentos Principais

GW10801F

Sigma-Aldrich

Anti-RNASE1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Anti-RNS1, Anti-Ribonuclease pancreatic

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41
conjugado:
unconjugated
application:
WB
clone:
polyclonal
reatividade de espécies:
human
citations:
3
técnica(s):
western blot: suitable

fonte biológica

chicken

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

reatividade de espécies

human

fabricante/nome comercial

Genway 15-288-10801F

técnica(s)

western blot: suitable

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... RNASE1(6035)

Imunogênio

Immunogen Sequence: GI # 4506547, sequence 1-156
Recombinant pancreatic ribonuclease

Aplicação

Anti-RNASE1 antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.

Ações bioquímicas/fisiológicas

RNASE1 encodes a protein that is a subset of the ribonuclease A superfamily. It is a pancreatic type of secretory ribonuclease. It acts on the 3′-side of pyrimidine bases and cleaves internal phosphodiester RNA bonds. It is a monomer and preferentially acts on ds-RNA over ss-RNA. Human RNAse I is involved in the digestion of dietary RNA, regulation of vascular homeostasis and inactivation of the HIV. It is also involved in the activation of immature dendritic cells and induction of cytokine production.

forma física

Solution in phosphate buffered saline containing 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Md Tabish Rehman et al.
PloS one, 6(3), e17159-e17159 (2011-03-17)
Human pancreatic ribonuclease (HPR), a member of RNase A superfamily, has a high activity on double stranded (ds) RNA. By virtue of this activity HPR appears to be involved in the host-defense against pathogenic viruses. To delineate the mechanism of
R Jeremy Johnson et al.
Journal of molecular biology, 368(2), 434-449 (2007-03-14)
The ribonuclease inhibitor protein (RI) binds to members of the bovine pancreatic ribonuclease (RNase A) superfamily with an affinity in the femtomolar range. Here, we report on structural and energetic aspects of the interaction between human RI (hRI) and human
K E Kövér et al.
Journal of molecular biology, 379(5), 953-965 (2008-05-23)
Human pancreatic ribonuclease (RNase 1) is expressed in many tissues; has several important enzymatic and biological activities, including efficient cleavage of single-stranded RNA, double-stranded RNA and double-stranded RNA-DNA hybrids, digestion of dietary RNA, regulation of vascular homeostasis, inactivation of the
Victoria J Mar et al.
Pigment cell & melanoma research, 27(6), 1117-1125 (2014-07-22)
Activating mutations in the GTPase RAC1 are a recurrent event in cutaneous melanoma. We investigated the clinical and pathological associations of RAC1(P29S) in a cohort of 814 primary cutaneous melanomas with known BRAF and NRAS mutation status. The RAC1(P29S) mutation

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