F8257

Flunarizine dihydrochloride

≥98% (TLC)

• Sinônimo(s): 1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
• Fórmula empírica (Notação de Hill): C₂₆H₂₆F₂N₂ · 2HCl
• Número CAS: 30484-77-6
• Peso molecular: 477.42
• Beilstein: 4284243
• Número CE: 250-216-6
• Número MDL: MFCD00058198
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277835
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (TLC)
• originador: Johnson & Johnson
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
• InChI: 1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
• chave InChI: RXKMOPXNWTYEHI-RDRKJGRWSA-N

Descrição

Descrição geral

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

Aplicação

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

Ações bioquímicas/fisiológicas

Blocks T-type Ca²⁺/Na⁺ channels; inhibits K⁺-induced catecholamine release from chromaffin cells

Características e benefícios

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves