D2069

Desvenlafaxine hydrochloride

≥98% (HPLC), powder

• Sinônimo(s): 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride
• Fórmula empírica (Notação de Hill): C₁₆H₂₅NO₂ · HCl
• Número CAS: 300827-87-6
• Peso molecular: 299.84
• Número MDL: MFCD11045287
• Código UNSPSC: 12352200
• ID de substância PubChem: 329798729
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• condição de armazenamento: desiccated
• cor: white to off-white
• solubilidade: DMSO: >20 mg/mL; H₂O: >20 mg/mL
• originador: Wyeth
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2
• InChI: 1S/C16H25NO2.ClH/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1H
• chave InChI: IMWPSXHIEURNKZ-UHFFFAOYSA-N

Descrição

Aplicação

Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.

Ações bioquímicas/fisiológicas

Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; K_i = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC₅₀ values of 47 and 531 nM.

Desvenlafaxine hydrochloride is a psychoactive drug. Incidence of this drug in environmental samples might induce in vitro gene expression associated with neurological disorders.

Características e benefícios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H319
• Declarações de precaução: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classificações de perigo: Eye Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves