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Key Documents

Outros documentos

D1068

Sigma-Aldrich

DCB

≥98% (HPLC), solid

Sinônimo(s):

3,3′-Dichlorobenzaldazine, NSC 67224

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About This Item

Fórmula empírica (Notação de Hill):
C14H10Cl2N2
Número CAS:
6971-97-7
Peso molecular:
277.15
Número MDL:
MFCD00556081
Código UNSPSC:
12352200
ID de substância PubChem:
24724458
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

condição de armazenamento

desiccated
under inert gas

cor

yellow

solubilidade

DMSO: ~6.8 mg/mL
H2O: insoluble

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1

InChI

1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+

chave InChI

XMOVWXSCYLINBJ-BEQMOXJMSA-N

Ações bioquímicas/fisiológicas

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).
Neutral allosteric modulator of the metabotropic glutamate receptor mGluR5.

Características e benefícios

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Diego L Wengier et al.
BMC plant biology, 18(1), 60-60 (2018-04-11)
Mitogen-activated protein kinases (MAPK) signaling affects many processes, some of which have different outcomes in the same cell. In Arabidopsis, activation of a MAPK cascade consisting of YODA, MKK4/5 and MPK3/6 inhibits early stages of stomatal developmental, but the ability
Yvonne Bausback et al.
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 24(4), 459-467 (2017-06-01)
To evaluate the performance of the Ranger paclitaxel-coated balloon vs uncoated balloon angioplasty for femoropopliteal lesions. Between January 2014 and October 2015, the prospective, randomized RANGER SFA study ( ClinicalTrials.gov identifier NCT02013193) enrolled 105 patients with symptomatic lower limb ischemia
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5
O'Brien JA, et al.
Molecular Pharmacology, 64(3), 731-740 (2003)
Dieuwertje Van der Does et al.
PLoS genetics, 13(6), e1006832-e1006832 (2017-06-13)
Plants actively perceive and respond to perturbations in their cell walls which arise during growth, biotic and abiotic stresses. However, few components involved in plant cell wall integrity sensing have been described to date. Using a reverse-genetic approach, we identified
Peter A Schneider et al.
Journal of the American College of Cardiology, 73(20), 2550-2563 (2019-01-29)
Five years of prospective clinical trials confirm that the paclitaxel drug-coated balloon (DCB) (IN.PACT Admiral, Medtronic, Dublin, Ireland) is safe and effective to treat femoropopliteal artery disease. A recent meta-analysis of heterogeneous trials of paclitaxel-based balloons and stents reported that
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