C6048

Cefmetazole sodium salt

• Fórmula linear: C₁₅H₁₆N₇O₅S₃Na
• Número CAS: 56796-39-5
• Peso molecular: 493.52
• Número MDL: MFCD00214260
• Código UNSPSC: 51282205
• ID de substância PubChem: 24278328
• NACRES: NA.85

Propriedades

• forma: powder
• Nível de qualidade: 200
• prazo de validade: limited shelf life, expiry date on the label
• solubilidade: H₂O: 50 mg/mL
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria
• Modo de ação: cell wall synthesis | interferes
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [Na+].[H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@]2(NC(=O)CSCC#N)OC)C([O-])=O
• InChI: 1S/C15H17N7O5S3.Na/c1-21-14(18-19-20-21)30-6-8-5-29-13-15(27-2,17-9(23)7-28-4-3-16)12(26)22(13)10(8)11(24)25;/h13H,4-7H2,1-2H3,(H,17,23)(H,24,25);/q;+1/p-1/t13-,15+;/m1./s1
• chave InChI: BITQGIOJQWZUPL-PBCQUBLHSA-M

Descrição

Descrição geral

Chemical structure: ß-lactam

Aplicação

Cefmetazole is used to study the effect of expression, binding, and inhibition of penicillin-binding proteins (PDPs) other than PBP2 on bacterial cell wall mucopeptide synthesis. Cefmetazole is used to study protein mediated transport of antibiotics.

Ações bioquímicas/fisiológicas

Cefmetazole disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cefmetazole mimics the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan. It is effective against both Gram-positive and Gram-negative bacteria.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic Handle and store under inert gas.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H315,H317,H319,H334,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable