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Key Documents

C5938

Sigma-Aldrich

Complement factor I from human plasma

>90% (SDS-PAGE)

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About This Item

Número CAS:
Número da licença da enzima:
Número MDL:
Código UNSPSC:
12352204
NACRES:
NA.54

fonte biológica

human plasma

Nível de qualidade

Ensaio

>90% (SDS-PAGE)

forma

solution

concentração

0.95-1.20 mg/mL

técnica(s)

activity assay: suitable

nº de adesão UniProt

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... CFI(3426)

Aplicação

Complement factor I from human plasma has been used in a case study of glucose-starved Staphylococcus aureus. Complement factor I from human plasma has also been used to study the human complement cascade of proteolysis as a target of laser irradiation.

Ações bioquímicas/fisiológicas

Protease which cleaves and inactivates C3b and C4b

forma física

Supplied as a 1mg/ml solution in PBS, pH 7.2

Outras notas

Exoneração de responsabilidade

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Código de classe de armazenamento

10 - Combustible liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Valérie Leroy et al.
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The development of membranoproliferative glomerulonephritis (MPGN) is associated with uncontrolled activation of the complement alternative pathway. This dysregulation is related either to C3 nephritic factor (C3NeF), an auto-antibody directed against the alternative C3 convertase, or to homozygous loss-of-function mutation of
No evidence of association between complement factor I genetic variant rs10033900 and age-related macular degeneration.
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European journal of human genetics : EJHG, 20(1), 1-2 (2011-10-13)
Maren Sullivan et al.
Annals of human genetics, 75(6), 639-647 (2011-09-13)
Hereditary atypical hemolytic uremic syndrome (aHUS), a dramatic disease frequently leading to dialysis, is associated with germline mutations of the CFH, CD46, or CFI genes. After identification of the mutation in an affected aHUS patient, single-site gene testing of relatives
G S Reusz et al.
Transplantation proceedings, 43(4), 1247-1249 (2011-05-31)
Hemolytic uremic syndrome (HUS) is a rare disease with various etiologies, making the identification of the specific forms and appropriate treatment difficult. Therefore, clinical and laboratory data from these patients need to be analyzed in national and international registries. Herein
Stephan Michalik et al.
Molecular & cellular proteomics : MCP, 11(9), 558-570 (2012-05-05)
The cellular amount of proteins not only depends on synthesis but also on degradation. Here, we expand the understanding of differential protein levels by complementing synthesis data with a proteome-wide, mass spectrometry-based stable isotope labeling with amino acids in cell

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