AV40487

Anti-EIF4G3 antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-Eukaryotic translation initiation factor 4 γ, 3
• Código UNSPSC: 12352203
• NACRES: NA.41
• clone: polyclonal
• application: WB
• reatividade de espécies: human
• técnica(s): western blot: suitable
• citations: 1

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: 57 kDa
• reatividade de espécies: human
• concentração: 0.5 mg - 1 mg/mL
• técnica(s): western blot: suitable
• nº de adesão NCBI: NP_003751
• nº de adesão UniProt: O43432-2
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... EIF4G3(8672)

Descrição

Descrição geral

Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) is involved in protein translation within the mammalian mRNA ribosome complex. EIF4G3 has been shown to be a target of cytotoxic T lymphocyte (CTL) produced granzyme B (GrB) suggesting that EIF4G3 may be targeted by CTL cells as a mechanism to inhibit the use of host translational machinery by infectious viruses.

Especificidade

Anti-EIF4G3 polyclonal antibody reacts with human, mouse, rat, and bovine eukaryotic translation initiation factor 4 gamma 3 proteins.

Imunogênio

Synthetic peptide directed towards the N terminal region of human EIF4G3

Aplicação

Anti-EIF4G3 polyclonal antibody is used to tag eukaryotic translation initiation factor 4 gamma 3 proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the role of eukaryotic translation initiation factor 4 gamma 3 in the initiation of mRNA translation and as a target of CTL cells during infectious virus assault.

Ações bioquímicas/fisiológicas

EIF4G3 is probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5′-terminal secondary structure and recruitment of mRNA to the ribosome. It is thought to be a functional homolog of EIF4G1.

Sequência

Synthetic peptide located within the following region: TAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIA

forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable