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A4336

Sigma-Aldrich

4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid

≥95% (HPLC)

Sinônimo(s):

FN-439

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About This Item

Fórmula empírica (Notação de Hill):
C23H34N6O6
Número CAS:
124168-73-6
Peso molecular:
490.55
Número MDL:
MFCD00237459
Código UNSPSC:
12352200
ID de substância PubChem:
24890847
NACRES:
NA.32

Ensaio

≥95% (HPLC)

Formulário

powder

solubilidade

H2O: 1 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC(C)C[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)c2ccc(N)cc2)C(=O)N[C@H](C)C(=O)NO

InChI

1S/C23H34N6O6/c1-13(2)11-17(22(33)26-14(3)20(31)28-35)27-23(34)18-5-4-10-29(18)19(30)12-25-21(32)15-6-8-16(24)9-7-15/h6-9,13-14,17-18,35H,4-5,10-12,24H2,1-3H3,(H,25,32)(H,26,33)(H,27,34)(H,28,31)/t14-,17-,18+/m1/s1

chave InChI

WWHUHFFMOPIVKB-OLMNPRSZSA-N

Informações sobre genes

human ... COL1A1(1277) , MMP1 (includes EG:4312)
mouse ... COL1A1(12842) , MMP1 (includes EG:4312)
rat ... COL1A1(29393) , MMP1 (includes EG:4312)

Amino Acid Sequence

Abz-Gly-Pro-Leu-Ala-HA

Ações bioquímicas/fisiológicas

Collagenase Inhibitor

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCBT9062
BCBH3406V
BCBB5780V
BCBB5780
1401735

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D R Garmer et al.
Proteins, 31(1), 42-60 (1998-04-29)
We investigated the binding properties of the metalloprotease inhibitors hydroxamate, methanethiolate, and methylphosphoramidate to a model coordination site occurring in several Zn2+ metalloproteases, including thermolysin. This was carried out using both the SIBFA (sum of interactions between fragments ab initio-computed)
H Anan et al.
Journal of endodontics, 22(12), 668-673 (1996-12-01)
To investigate the effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) in the root canal treatment of apical periodontitis, we studied the healing process of experimentally induced periapical lesions in rats by using immunohistochemical
S Odake et al.
Chemical & pharmaceutical bulletin, 39(6), 1489-1494 (1991-06-01)
To develop a potent and specific collagenase inhibitor, a series of tetrapeptidyl hydroxamic acids were synthesized, based on the previous findings with tripeptidyl derivatives (Chem. Pharm. Bull., 38, 1007-1011, 1990). Among the series of tetrapeptidyl derivatives synthesized, R-Gly-Pro-Leu-Ala-NHOH and R-Gly-Pro-D-Leu-D-Ala-NHOH
S Odake et al.
Biochemical and biophysical research communications, 199(3), 1442-1446 (1994-03-30)
Synthetic inhibitors of interstitial collagenase, tri- and tetrapeptidyl hydroxamic acids, have been developed and tested for their inhibitory activities against human matrix metalloproteinases. A water soluble inhibitor, p-NH2-Bz-Gly-Pro-D-Leu-D-Ala-NHOH (FN-439) inhibited interstitial and granulocyte collagenases, granulocyte gelatinase and skin fibroblast stromelysin
Lina María Preciado et al.
Toxins, 12(1) (2019-12-22)
Snake bite envenoming is a public health problem that was recently included in the list of neglected tropical diseases of the World Health Organization. In the search of new therapies for the treatment of local tissue damage induced by snake
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