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A3913

Sigma-Aldrich

L-Argininamide dihydrochloride

≥98%, suitable for ligand binding assays

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About This Item

Fórmula empírica (Notação de Hill):
C6H15N5O · 2HCl
Número CAS:
14975-30-5
Peso molecular:
246.14
Número MDL:
MFCD00058286
Código UNSPSC:
12352209
ID de substância PubChem:
24890827
NACRES:
NA.26

product name

L-Argininamide dihydrochloride,

Ensaio

≥98%

forma

powder

técnica(s)

ligand binding assay: suitable

cor

white to off-white

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.N[C@@H](CCCNC(N)=N)C(N)=O

InChI

1S/C6H15N5O.ClH/c7-4(5(8)12)2-1-3-11-6(9)10;/h4H,1-3,7H2,(H2,8,12)(H4,9,10,11);1H/t4-;/m0./s1

chave InChI

BPQLYFCEVVKLLX-WCCKRBBISA-N

Aplicação

L-Argininamide dihydrochloride has been used as an additive to compare its effect over L-arg in egg lysozyme refolding studies. It has also been used as a component of substrate stock solution for enzymatic kyotorphin synthesis.

Ações bioquímicas/fisiológicas

L-Argininamide (L-Arm) is a hydrophilic amino acid derivative that is used as a model compound in physicochemical characteristic studies of ligand binding DNA aptamers and their potential development as fluorescent aptasensors.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Danger

Frases de perigo

H302,H370

Classificações de perigo

Acute Tox. 4 Oral - STOT SE 1

Órgãos-alvo

Eyes

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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G Reid Bishop et al.
Biophysical chemistry, 126(1-3), 165-175 (2006-08-18)
The thermal stability and ligand binding properties of the L-argininamide-binding DNA aptamer (5'-GATCGAAACGTAGCGCCTTCGATC-3') were studied by spectroscopic and calorimetric methods. Differential calorimetric studies showed that the uncomplexed aptamer melted in a two-state reaction with a melting temperature T(m)=50.2+/-0.2 degrees C
Qi Zhang et al.
Science (New York, N.Y.), 311(5761), 653-656 (2006-02-04)
Using a domain elongation strategy, we decoupled internal motions in RNA from overall rotational diffusion. This allowed us to site-specifically resolve a manifold of motional modes in two regulatory RNAs from HIV-1 with the use of nuclear magnetic resonance spin
RNA dynamics by design: biasing ensembles towards the ligand-bound state.
Andrew C Stelzer et al.
Angewandte Chemie (International ed. in English), 49(33), 5731-5733 (2010-06-29)
Zece Zhu et al.
Chemical communications (Cambridge, England), 47(11), 3192-3194 (2011-01-29)
The nucleic acid minor groove binding dyes, DAPI and Hoechst 33258, were for the first time used in label-free aptamer-based sensors for L-argininamide. The synergy binding effect results in the enhancement of fluorescence of dyes. The method for detection of
Max Keller et al.
Bioorganic & medicinal chemistry, 19(9), 2859-2878 (2011-04-16)
Fluorescently labelled NPY Y(1) receptor (Y(1)R) ligands were synthesized by connecting pyrylium and cyanine dyes with the argininamide-type Y(1)R antagonist core structure by linkers, covering a wide variety in length and chemical nature, attached to the guanidine group. The most
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