95200

Vitamin B_12a hydrochloride

≥96% (UV), ≥96% (HPLC)

• Sinônimo(s): Hydroxocobalamin hydrochloride
• Fórmula empírica (Notação de Hill): C₆₂H₈₉CoN₁₃O₁₅P · HCl
• Número CAS: 59461-30-2
• Peso molecular: 1382.82
• Número CE: 261-772-4
• Número MDL: MFCD00167463
• Código UNSPSC: 12352205
• ID de substância PubChem: 57653658
• NACRES: NA.79

Propriedades

• fonte biológica: fermentation/recombinant
• Nível de qualidade: 100
• Ensaio: ≥96% (HPLC); ≥96% (UV)
• forma: powder or crystals
• perda: ≤12% loss on drying, 20 °C (HV)
• cor: red to dark red
• solubilidade: methanol: 10 mg/mL at 20 °C, clear, dark red
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N([Co+]O)C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78
• InChI: 1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H;;1H2/q;;+3;/p-3/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;;/m1.../s1
• chave InChI: KEHNCSYXYMMUCO-BXSGNKEGSA-K

Descrição

Aplicação

Vitamin B12a hydrochloride has been used as an antidote for cyanide poisoning.

Ações bioquímicas/fisiológicas

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

Outras notas

Review

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)