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352M-9

Napsin A (MRQ-60) Mouse Monoclonal Antibody

Name: Napsin A (MRQ-60) Mouse Monoclonal Antibody
Brand: SIGMA

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

Produtos recomendados

Slide 1 of 1

1 of 1

Sigma-Aldrich

SAB5600254

Anti-Napsin-A antibody, Rabbit monoclonal

fonte biológica

mouse

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

MRQ-60, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulário

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (352M-94)
vial of 0.5 mL concentrate (352M-95)
bottle of 1.0 mL predilute (352M-97)
vial of 1.0 mL concentrate (352M-96)
bottle of 7.0 mL predilute (352M-98)

fabricante/nome comercial

Cell Marque^™

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotipo

IgG1κ

controle

lung adenocarcinoma, renal cell carcinoma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

cytoplasmic

Informações sobre genes

human ... NAPSA(9476)

Descrição geral

Napsin is a pepsin-like aspartic proteinase in the A1 clan of the AA clade ofproteinases. Napsin A is involved in processing propeptide pulmonary surfactant protein B(proSP-B) in the lung. In normal, benign tissue, Napsin A has expressed in type II pneumocytesof the lung and proximal tubules of the kidney. Napsin A is a useful marker for lungadenocarcinoma.

Qualidade

IVD

RUO

Ligação

Napsin A Positive Control Slides, Product No. 352S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Lot/Batch Number

0000292380

1417501A-Z

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Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung.

Frank Brasch et al.

The Journal of biological chemistry, 278(49), 49006-49014 (2003-09-18)

Surfactant protein B (SP-B) is a critical component of pulmonary surfactant, and a deficiency of active SP-B results in fatal respiratory failure. SP-B is synthesized by type-II pneumocytes as a 42-kDa propeptide (proSP-B), which is posttranslationally processed to an 8-kDa

Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung.

Jaishree Jagirdar

Archives of pathology & laboratory medicine, 132(3), 384-396 (2008-03-06)

Immunohistochemistry is a very valuable and often used tool in the differential diagnosis of lung carcinomas whether primary or secondary to the lung. The most useful application is in distinguishing primary lung tumors from metastatic tumors to the lung from

Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma.

Justin A Bishop et al.

Human pathology, 41(1), 20-25 (2009-09-11)

Recent advances in the treatment of pulmonary adenocarcinoma have increased the need for accurate typing of non-small cell carcinomas. Immunohistochemistry for thyroid transcription factor-1 is widely used in the diagnosis of pulmonary adenocarcinomas because it marks approximately 75% of lung

Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung.

Jiqing Ye et al.

Applied immunohistochemistry & molecular morphology : AIMM, 19(4), 313-317 (2011-04-06)

Differentiation of primary from metastatic adenocarcinoma in the lung can be challenging, and it demands sensitive and specific biomarkers, especially when the tissue for diagnosis is limited. Thyroid transcription factor-1 (TTF-1) has been considered a reliable marker for adenocarcinoma of

Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions.

Annika Dejmek et al.

Diagnostic cytopathology, 35(8), 493-497 (2007-07-20)

The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on formalin-fixed paraffin embedded

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