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Key Documents

352A-7

Napsin A Rabbit Polyclonal Antibody

Name: Napsin A Rabbit Polyclonal Antibody
Brand: SIGMA

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

Ig fraction of antiserum

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

forma

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (352A-74)
vial of 0.5 mL concentrate (352A-75)
bottle of 1.0 mL predilute (352A-77)
vial of 1.0 mL concentrate (352A-76)
bottle of 7.0 mL predilute (352A-78)

fabricante/nome comercial

Cell Marque^™

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

controle

kidney, lung adenocarcinoma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

cytoplasmic

Categorias relacionadas

Cell Marque

Cell Marque™ Primary Antibodies

Clinical & Diagnostics

Descrição geral

Napsin is a pepsin-like aspartic proteinase, in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.

Qualidade

IVD

RUO

Ligação

Napsin A Positive Control Slides, Product No. 352S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung.

Jaishree Jagirdar

Archives of pathology & laboratory medicine, 132(3), 384-396 (2008-03-06)

Immunohistochemistry is a very valuable and often used tool in the differential diagnosis of lung carcinomas whether primary or secondary to the lung. The most useful application is in distinguishing primary lung tumors from metastatic tumors to the lung from

Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma.

Justin A Bishop et al.

Human pathology, 41(1), 20-25 (2009-09-11)

Recent advances in the treatment of pulmonary adenocarcinoma have increased the need for accurate typing of non-small cell carcinomas. Immunohistochemistry for thyroid transcription factor-1 is widely used in the diagnosis of pulmonary adenocarcinomas because it marks approximately 75% of lung

Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung.

Jiqing Ye et al.

Applied immunohistochemistry & molecular morphology : AIMM, 19(4), 313-317 (2011-04-06)

Differentiation of primary from metastatic adenocarcinoma in the lung can be challenging, and it demands sensitive and specific biomarkers, especially when the tissue for diagnosis is limited. Thyroid transcription factor-1 (TTF-1) has been considered a reliable marker for adenocarcinoma of

Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions.

Annika Dejmek et al.

Diagnostic cytopathology, 35(8), 493-497 (2007-07-20)

The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on formalin-fixed paraffin embedded

Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas.

Kentaro Inamura et al.

The American journal of surgical pathology, 29(5), 660-665 (2005-04-16)

Primary pulmonary adenocarcinomas with enteric differentiation (PAED) are mainly composed of tall-columnar cells that show similarity to intestinal epithelia and colorectal carcinomas. In this study, we analyzed the immunostaining profiles of 7 PAEDs in comparison with 14 metastatic colorectal carcinomas

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