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343R-1

Sigma-Aldrich

TTF-1 (EP229) Rabbit Monoclonal Primary Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

EP229, monoclonal

descrição

(For In Vitro Diagnostic Use in Select Regions (See Chart))

Formulário

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (343R-14)
vial of 0.5 mL concentrate (343R-15)
bottle of 1.0 mL predilute (343R-17)
vial of 1.0 mL concentrate (343R-16)
bottle of 7.0 mL predilute (343R-18)

fabricante/nome comercial

Cell Marque®

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

Isotipo

IgG

controle

lung adenocarcinoma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

nuclear

Informações sobre genes

human ... A1CF(29974)

Categorias relacionadas

Descrição geral

Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid1-2, germ cell tumors3, and malignant mesothelioma.4-5 It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.6 TTF-1 labeling is also seen in thyroid and thyroid-derived tumors.7 TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions.8 TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large-cell carcinomas.9

Qualidade


IVD
IVD
IVD
RUO

Ligação

TTF-1 Positive Control Slides, Product No. 343S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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1502104A-Z
1502103A-Z

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A R Altman et al.
Gastroenterology, 77(6), 1211-1216 (1979-12-01)
A family was studied in which three middle-aged siblings had unexplained cirrhosis and steatosis. Five of nine additional family members had abnormalities of liver function. Liver biopsy in those 5 revealed steatosis in 3, steatosis and fibrosis in 1, and
P A Bejarano et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 9(4), 445-452 (1996-04-01)
Antibodies to the pulmonary epithelial cell-specific proteins surfactant proteins A and B (SP-A and SP-B) and to thyroid transcription factor-1 (TTF-1), a homeodomain nuclear transcription protein, were used as immunohistochemical markers to asses their ability to distinguish primary pulmonary non-small
C Di Loreto et al.
Cancer letters, 124(1), 73-78 (1998-03-21)
TTF-1 is a tissue-specific transcription factor expressed in the epithelial cells of thyroid and lung. This study investigates the immunohistochemical expression of TTF-1 in pleural malignant mesotheliomas (MM) and adenocarcinomas (AC) of the lung, respectively. For this purpose, 33 biopsy
R Katoh et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 13(5), 570-576 (2000-05-29)
Thyroid transcription factor-1 (TTF-1) has been known to regulate the transcriptional activity of thyroid-specific genes. We examined the expression of TTF-1 in non-neoplastic and neoplastic thyroid tissues. By immunohistochemistry, the nuclei of normal and hyperplastic follicular cells strongly reacted with
K Y Jang et al.
Analytical and quantitative cytology and histology, 23(6), 400-404 (2002-01-05)
To estimate the utility of thyroid transcription factor-1 (TTF-1) and the combined cytokeratin 7 (CK7) and 20 (CK20) immunoprofile as a marker for identifying the primary site of metastatic adenocarcinoma in effusions of the serous cavity. Formalin-fixed, paraffin-embedded cell block
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