Y0001599

Wedelolactone

European Pharmacopoeia (EP) Reference Standard

• Sinônimo(s): 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, 7-Methoxy-5,11,12-trihydroxycoumestan
• Fórmula empírica (Notação de Hill): C₁₆H₁₀O₇
• Número CAS: 524-12-9
• Peso molecular: 314.25
• Número MDL: MFCD07778564
• Código UNSPSC: 41116107
• ID de substância PubChem: 329831504
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: wedelolactone
• fabricante/nome comercial: EDQM
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1
• InChI: 1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
• chave InChI: XQDCKJKKMFWXGB-UHFFFAOYSA-N

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Wedelolactone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC₅₀ < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1