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Y0001023

Nicotine for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

(−)-Nicotine hydrogen tartrate salt, (−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt

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About This Item

Fórmula empírica (Notação de Hill):
C10H14N2 · 2C4H6O6
Número CAS:
65-31-6
Peso molecular:
462.41
Código UNSPSC:
41116107
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

nicotine

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CN1CCC[C@H]1C2=CC=CN=C2.C

InChI

1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1

chave InChI

RYYKFQGHMYGLEL-PPHPATTJSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Nicotine for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

produto relacionado

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1463304

Nicotine bitartrate dihydrate, United States Pharmacopeia (USP) Reference Standard

1327408

6-Hydroxynicotinic acid, United States Pharmacopeia (USP) Reference Standard

1463371

Nicotine Related Compound F, United States Pharmacopeia (USP) Reference Standard

1463337

Nicotine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1463382

Nicotine Related Compound G, United States Pharmacopeia (USP) Reference Standard

1463326

Nicotine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1463348

Nicotine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1463360

Nicotine Related Compound E, United States Pharmacopeia (USP) Reference Standard

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Nicotine Related Compound D, United States Pharmacopeia (USP) Reference Standard

BP822

Nicotine impurity standard, British Pharmacopoeia (BP) Reference Standard

BP821

(−)-Nicotine hydrogen tartrate salt dihydrate, British Pharmacopoeia (BP) Reference Standard

PHR2533

Nicotine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2532

Nicotine bitartrate dihydrate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3061

Nicotine Related Compound B, pharmaceutical secondary standard, certified reference material

PHR3064

Nicotine Related Compound G, pharmaceutical secondary standard, certified reference material

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2

Código de classe de armazenamento

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

289.8 °F

Ponto de fulgor (°C)

143.2 °C

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Certificados de análise (COA)

Lot/Batch Number

Lamentamos, não temos COA para este produto disponíveis online no momento.

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(-)-Nicotine for synthesis

Sigma-Aldrich

8.20877

(-)-Nicotine

(±)-Nicotine ≥99% (TLC), liquid

Sigma-Aldrich

N0267

(±)-Nicotine

Matthew L Banks
Experimental and clinical psychopharmacology, 22(3), 266-273 (2014-02-20)
Preclinical drug discrimination procedures have been useful in understanding the pharmacological mechanisms of the subjective-like effects of abused drugs. Converging lines of evidence from neurochemical and behavioral studies implicate a potential role of nicotinic acetylcholine (nACh) receptors in the abuse-related
June Bryan de la Peña et al.
Behavioural brain research, 272, 156-164 (2014-07-06)
Nicotine/cigarette addiction starts young. Indeed, most smokers started when they were adolescents. Adolescence has been implicated to be a critical period for nicotine/cigarette addiction, thus it is important to understand the consequences of such early exposure. In the present study
Yuan-yuan Zhang et al.
Acta pharmacologica Sinica, 35(9), 1137-1149 (2014-08-05)
The non-neuronal acetylcholine system (NNAS) in endothelial cells participates in modulating endothelial function, vascular tone, angiogenesis and inflammation, thus plays a critical role in cardiovascular diseases. In this study, we used a proteomic approach to study potential downstream receptor-effectors of
Raphaël Eddine et al.
Scientific reports, 5, 8184-8184 (2015-02-03)
Midbrain dopamine (DA) neurons are key players in motivation and reward processing. Increased DA release is thought to be central in the initiation of drug addiction. Whereas dopamine neurons are generally considered to be activated by drugs such as nicotine
P P Muldoon et al.
British journal of pharmacology, 172(3), 869-882 (2014-09-27)
Abrupt discontinuation of nicotine, the main psychoactive component in tobacco, induces a withdrawal syndrome in nicotine-dependent animals, consisting of somatic and affective signs, avoidance of which contributes to drug maintenance. While blockade of fatty acid amide hydrolase, the primary catabolic

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