PHR1736

Venlafaxine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): Venlafaxine hydrochloride, (+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride, Effexor
• Fórmula empírica (Notação de Hill): C₁₇H₂₇NO₂ · HCl
• Número CAS: 99300-78-4
• Peso molecular: 313.86
• Número MDL: MFCD03658865
• Código UNSPSC: 41116107
• ID de substância PubChem: 329823583
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to BP 835; traceable to Ph. Eur. Y0000587; traceable to USP 1711268
• família API: venlafaxine
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 1 g
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: 2-30°C
• cadeia de caracteres SMILES: Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2
• InChI: 1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
• chave InChI: QYRYFNHXARDNFZ-UHFFFAOYSA-N
• Informações sobre genes: human ... SLC6A2(6530) , SLC6A4(6532)

Descrição

Descrição geral

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Venlafaxine Hydrochloride is the hydrochloride salt of venlafaxine, a non-tricyclic antidepressant and serotonin-norepinephrine-dopamine reuptake inhibitor.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Venlafaxine Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high performance liquid chromatography technique. It is also used as a secondary pharmaceutical standard for the determination of venlafaxine in pharmaceutical formulations using liquid chromatography technique.

Ações bioquímicas/fisiológicas

Venlafaxine is an antidepressant. The mechanism of the antidepresant action of venlafaxine in humans is associated with its potentiation of neurotransmitter activity in the CNS. Venlafaxine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitor of dopamine reuptake. Venlafaxine has no significant activity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. Venlafaxine does not possess MAO inhibitor activity.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAB7761 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Pictogramas: GHS09
• Frases de perigo: H411
• Declarações de precaução: P273 - P391 - P501
• Classificações de perigo: Aquatic Chronic 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable