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N2144

Supelco

Norfludiazepam

analytical standard

Sinônimo(s):

7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one, Desalkylflurazepam

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About This Item

Fórmula empírica (Notação de Hill):
C15H10ClFN2O
Número CAS:
2886-65-9
Peso molecular:
288.70
Número CE:
220-748-3
Número MDL:
MFCD00083443
Código UNSPSC:
41116107
ID de substância PubChem:
329818597

grau

analytical standard

Ensaio

≥98%

controle de medicamentos

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); regulated under CDSA - not available from Sigma-Aldrich Canada

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

Fc1ccccc1C2=NCC(=O)Nc3ccc(Cl)cc23

InChI

1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)

chave InChI

UVCOILFBWYKHHB-UHFFFAOYSA-N

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Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ações bioquímicas/fisiológicas

The major human metabolite of flurazepam

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H336

Classificações de perigo

STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
118K4015
066K4029
118K4015
048K4131
097K4073

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

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S Dunlop et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1064, 22-27 (2017-09-11)
The objective of this work was to establish an analytical method for the analysis of 7 Benzodiazepines (diazepam, oxazepam, temazepam, nordiazepam, desalkylflurazepam, alprazolam and α-hydroxyalprazolam) in urine specimens taken from drivers suspected of driving under the influence of drugs. The
J Hilbert et al.
Drug metabolism and disposition: the biological fate of chemicals, 12(4), 452-459 (1984-07-01)
The disposition of 14C-quazepam (7-chloro-(2,2,2-trifluoroethyl) [5-14C]-5-o-fluorophenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-thione), a new benzodiazepine hypnotic, was studied in hamsters and mice after iv and po dosing. In both species, quazepam was rapidly absorbed, as indicated by the plasma Cmax being reached within 1 hr of
Matteo Moretti et al.
Drug testing and analysis, 11(9), 1403-1411 (2019-05-28)
We successfully developed and validated an LC-MS/MS method for the identification of 27 and quantification of 9 benzodiazepines and metabolites in whole blood and DBSs. The results provided a good qualitative and quantitative correlation between DBSs stored at room temperature
Y Sakai et al.
Japanese journal of pharmacology, 37(4), 373-379 (1985-04-01)
A new benzodiazepine compound, ethyl loflazepate (ethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-2-oxo-1H,1,4- benzodiazepine-3-carboxylate; CM6912) was studied using in vitro experimental systems for its displacement activity on 3H-diazepam binding to the synaptosomal membrane fraction of rat cerebrum and potentiating action on GABA. CM6912 inhibited the specific
S K Gupta et al.
Pharmaceutical research, 5(6), 365-368 (1988-06-01)
A reverse-phase liquid chromatographic method is described for simultaneous quantification of quazepam, and two of its metabolites, 2-oxoquazepam and N-desaklyl-2-oxoquazepam. The method uses a solid-phase extraction procedure to prepare plasma samples. After extraction, the methanolic extract is evaporated; the residue
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