RV2MAG-26K

MILLIPLEX^® Rat Vascular Injury Magnetic Bead Panel 2 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: Adiponectin, sE-Selectin, and sICAM-1.

• Sinônimo(s): Luminex^® Rat Vascualr Injury Panel, Millipore Rat Vascualr Injury Panel, Rat Adiponectin Assay, Rat Vascular Injury Multiplex Assay
• Código UNSPSC: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

Propriedades

• Nível de qualidade: 200
• reatividade de espécies: rat
• fabricante/nome comercial: Milliplex^®
• assay range: accuracy: 67-92%; standard curve range: 0.1-40 ng/mL; (sICAM-1); standard curve range: 0.1-50 ng/mL; (sE-Selectin); standard curve range: 0.3-250 ng/mL; (Adiponectin); standard curve range: 0.7-500 ng/mL; (von Willebrand Factor (vWF))
• técnica(s): multiplexing: suitable
• método de detecção: fluorometric (Luminex xMAP)
• Condições de expedição: wet ice

Descrição

Descrição geral

Vascular injury is important to address during the preclinical safety study of drugs. A lack of well-defined mechanisms of drug-induced vascular injury (DIVI) in animals, and the absence of specific, qualified biomarkers have become significant barriers in the development of new therapeutic treatments. In the past, hemodynamics, such as heart rate and mean arterial blood pressure, were used to measure DIVI risks but these only targeted single biomarkers. Today, some of the known vascular injury mechanisms are related to vascular wall shear and/or circumferential “hoop” stress, drug/chemical toxicity, and immunological mediation. With these known biomechanics, primary targets (smooth muscle, endothelial and immune-mediated cells) yield a number of promising candidate biomarkers for DIVI study. We provide valuable research assays to investigate multiple biomarkers of vascular injury in rat serum and plasma samples using the Luminex^® xMAP^® instrument platform.

The MILLIPLEX^® Rat Vascular Injury Bead Panel 2 contains all the components necessary to measure the following four biomarkers in any combination using Luminex^® xMAP^® technology: Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF). The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.

Panel Type: Toxicity

Especificidade

There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Aplicação

• Analytes: Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF)
• Recommended Sample type: serum and plasma
• Recommended Sample dilution: 1:80
• Assay Run Time: Overnight
• Research Category: Toxicity

Características e benefícios

Design your multiplex kit by choosing available analytes within this panel.

Embalagem

Everything you need in a single kit.

Armazenamento e estabilidade

Recommended storage for kit components is 2 - 8°C.

Outras notas

Please contact Technical Service for linearity of dilution.

Sensitivity: See kit protocol for individual analytes sensitivities.

Informações legais

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H302 + H332,H311,H317,H411
• Declarações de precaução: P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Classificações de perigo: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects