PC41
Anti-Cathepsin B (Ab-3) Rabbit pAb
liquid, Calbiochem®
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About This Item
Código UNSPSC:
12352203
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
purified antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
liquid
contém
≤0.1% sodium azide as preservative
reatividade de espécies
human
fabricante/nome comercial
Calbiochem®
condição de armazenamento
do not freeze
Isotipo
IgG
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Descrição geral
Anti-Cathepsin B (Ab-3), rabbit polyclonal, recognizes the ~43 kDa latent and ~31 kDa active forms of cathepsin B in breast carcinoma. It is validated for Western blotting and for paraffin sections.
Purified rabbit polyclonal antibody. Recognizes the ~43 kDa latent and the ~31 kDa active forms of cathepsin B.
Recognizes the ~43 kDa latent and the ~31 kDa active forms of cathepsin B in breast carcinoma tissues.
Imunogênio
Human
purified human liver cathepsin B
Aplicação
Immunoblotting (1 µg/ml)
Paraffin Sections (2.5 µg/ml, trypsin pre-treatment required)
Paraffin Sections (2.5 µg/ml, trypsin pre-treatment required)
Embalagem
Please refer to vial label for lot-specific concentration.
Advertência
Toxicity: Standard Handling (A)
forma física
In 0.05 M sodium phosphate buffer, 0.2% gelatin.
Nota de análise
Positive Control
SK-HEP-1 concentrated conditioned medium or breast carcinoma tissue
SK-HEP-1 concentrated conditioned medium or breast carcinoma tissue
Outras notas
Antibody should be titrated for optimal results in individual systems.
Barrett, A.J. and Kirschke, H. 1981. Methods Enzymol.80, 535.
Chan, S.J., et al. Proc. Natl. Acad. Sci. USA83, 7721.
Barrett, A.J. 1987. Trends Biochem. Sci.12, 193.
Sloane, B.F. 1990. in Seminars in Cancer Biology, ed. M. M. Gottesman. Vol. 1(2), 137.
Chan, S.J., et al. Proc. Natl. Acad. Sci. USA83, 7721.
Barrett, A.J. 1987. Trends Biochem. Sci.12, 193.
Sloane, B.F. 1990. in Seminars in Cancer Biology, ed. M. M. Gottesman. Vol. 1(2), 137.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
B F Sloane
Seminars in cancer biology, 1(2), 137-152 (1990-04-01)
The cysteine proteinase cathepsin B has been implicated in the progression of tumors from a premalignant to a malignant state. Activity of cathepsin B has been shown to be elevated in parallel with malignancy or metastatic potential of human and
S J Chan et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(20), 7721-7725 (1986-10-01)
Cathepsin B is a lysosomal thiol proteinase that may have additional extralysosomal functions. To further our investigations on the structure, mode of biosynthesis, and intracellular sorting of this enzyme, we have determined the complete coding sequences for human and mouse
Paola Pellegrini et al.
Autophagy, 10(4), 562-571 (2014-02-05)
Acidic pH is an important feature of tumor microenvironment and a major determinant of tumor progression. We reported that cancer cells upregulate autophagy as a survival mechanism to acidic stress. Inhibition of autophagy by administration of chloroquine (CQ) in combination
Xian Zhang et al.
iScience, 19, 607-622 (2019-08-26)
Transforming growth factor beta (TGF-β) signaling contributes to tissue fibrosis. Here we demonstrate that TGF-β enhances CatS and CatK expression but reduces CatB and CatL expression in mouse kidney tubular epithelial cells (TECs). CatS- and CatK deficiency reduces TEC nuclear
Cathepsin B, Cathepsin H, and cathepsin L.
A J Barrett et al.
Methods in enzymology, 80 Pt C, 535-561 (1981-01-01)
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