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MAB4331

Sigma-Aldrich

Anti-MELK Antibody, clone 6C1.3

clone 6C1.3, Chemicon®, from mouse

Sinônimo(s):

Maternal Embryonic Leucine Zipper Kinase

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

6C1.3, monoclonal

reatividade de espécies

human

fabricante/nome comercial

Chemicon®

técnica(s)

western blot: suitable

entrada

sample type neural stem cell(s)

Isotipo

IgG2κ

nº de adesão NCBI

NM_014791.2

nº de adesão UniProt

Q14680

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... MELK(9833)

Descrição geral

Melk, (Maternal Embryonic Leucine Zipper Kinase) is a serine-threonine kinase of the snfI/AMPK family that is expressed in developing neuroepithelium, self-renewing neural stem cells and granule cell precursors. It is also considered an important brain tumor marker, being highly expressed in gliobastoma, astrocytomas, and medulablastomas.

Imunogênio

MELK Recombinant protein.

Aplicação

Research Category
Stem Cell Research
Research Sub Category
Neural Stem Cells
This Anti-MELK Antibody, clone 6C1.3 is validated for use in WB for the detection of MELK.
Western blot: Recommended dilution: 1:500 (2 μg/mL)
Expected Molecular Weight: 74.5 kDa
Note: Bands may be present at a higher molecular weight due to glycosolation.

Descrição-alvo

74.5 kDA; glycosylations may result in higher MW bands in western blot.

forma física

Format: Purified
Purified immunoglobulin in PBS, pH 7.0. Contains 0.1% sodium azide.

Armazenamento e estabilidade

1 year at 2-8 °C from date of shipment

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Lieve Verlinden et al.
The Journal of biological chemistry, 280(45), 37319-37330 (2005-09-08)
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) has potent antiproliferative effects characterized by a hampered G(1)/S transition. cDNA microarrays were used to monitor expression of 21,492 genes in MC3T3-E1 mouse osteoblasts at 1, 6, 12, 24, and 36 h after treatment with 1,25(OH)(2)D(3). Statistical
Mathew C Easterday et al.
Developmental biology, 264(2), 309-322 (2003-12-04)
The identification of the genes regulating neural progenitor cell (NPC) functions is of great importance to developmental neuroscience and neural repair. Previously, we combined genetic subtraction and microarray analysis to identify genes enriched in neural progenitor cultures. Here, we apply
Ichiro Nakano et al.
The Journal of cell biology, 170(3), 413-427 (2005-08-03)
Maternal embryonic leucine zipper kinase (MELK) was previously identified in a screen for genes enriched in neural progenitors. Here, we demonstrate expression of MELK by progenitors in developing and adult brain and that MELK serves as a marker for self-renewing

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