MAB1820
Anti-Scribble Antibody
clone 7C6.D10, Chemicon®, from mouse
Sinônimo(s):
Scrib, LAP4
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified antibody
tipo de produto de anticorpo
primary antibodies
clone
7C6.D10, monoclonal
reatividade de espécies
human
fabricante/nome comercial
Chemicon®
técnica(s)
western blot: suitable
Isotipo
IgG1κ
nº de adesão GenBank
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... SCRIB(23513)
Descrição geral
Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).
Especificidade
Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.
Imunogênio
Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble
Aplicação
Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Western blot: 0.2 µg (1:2000)
Research Sub Category
Tumor Markers
Cytoskeleton
Tumor Markers
Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.
Qualidade
Routinely evaluated by Western blot on HeLa cell lysates.
Descrição-alvo
220 kDa
forma física
Format: Purified
Purified in PBS containing with 0.05% NaN3.
Armazenamento e estabilidade
Maintain at 2-8°C for up to 1 year after date of receipt.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
L E Dow et al.
Oncogene, 26(16), 2272-2282 (2006-10-18)
Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear. Mutations in Drosophila Scribble result in loss of polarity, overproliferation and 3D-tumourous overgrowth of epithelial cells. Using complementation studies in Drosophila
Mandy J Ludford-Menting et al.
Immunity, 22(6), 737-748 (2005-06-21)
T cell shape is dictated by the selective recruitment of molecules to different regions of the cell (polarity) and is integral to every aspect of T cell function, from migration to cytotoxicity. This study describes a mechanism for the regulation
Lukas E Dow et al.
Oncogene, 22(58), 9225-9230 (2003-12-19)
Scribble (scrib), discs large (dlg) and lethal giant larvae (lgl) encode proteins that regulate cell polarity and have been identified as neoplastic tumour suppressor genes in Drosophila melanogaster. Here, we have used the Drosophila model system to provide the first
Patrick Humbert et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 25(6), 542-553 (2003-05-27)
Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been
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