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Documentos Principais

MAB1293

Sigma-Aldrich

Anti-DNA Antibody, double stranded, clone AE-2

clone AE-2, Chemicon®, from mouse

Sinônimo(s):

Double-stranded DNA antibody

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

AE-2, monoclonal

reatividade da espécie (prevista por homologia)

all

fabricante/nome comercial

Chemicon®

técnica(s)

immunocytochemistry: suitable
immunohistochemistry: suitable

Isotipo

IgG3

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Especificidade

Double stranded DNA. MAB1293 produces a homogeneous staining pattern in the nucleus of normal and malignant cells.

Imunogênio

Epitope: double stranded
Nuclei of Raji Burkitt′s lymphoma cells

Aplicação

Anti-DNA Antibody, double stranded, clone AE-2 is a high quality Mouse Monoclonal Antibody for the detection of DNA & has been validated in ICC & IHC.
Immunocytochemistry: paraformaldehyde fixed cell preparations

Immunohistochemistry: paraformaldehyde fixed frozen tissue sections

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected double stranded DNA in human prostrate and tonsil tissue sections.

Optimal working dilutions must be determined by the end user.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

forma física

Format: Purified
Purified immunoglobulin. Liquid in 0.02M Phosphate buffer with 0.25 NaCl and 0.1% sodium azide.

Armazenamento e estabilidade

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Nota de análise

Control
POSITIVE CONTROL: Human tonsil

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Manuel Adrian Suter et al.
Scientific reports, 11(1), 7243-7243 (2021-04-02)
Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA and subsequent activation of the STING signaling pathway. Here, we show that the cGAS-STING
Yang Liu et al.
Scientific reports, 6, 18696-18696 (2016-01-05)
Iridovirid infection is associated with the catastrophic loss in aquaculture industry and the population decline of wild amphibians and reptiles, but none of the iridovirid life cycles have been well explored. Here, we report the detailed visualization of the life
Weiwei Wang et al.
Molecular cancer research : MCR, 20(7), 1137-1150 (2022-03-30)
Targeting the DNA damage response in combination with radiation enhances type I interferon (T1IFN)-driven innate immune signaling. It is not understood, however, whether DNA-dependent protein kinase (DNA-PK), the kinase critical for repairing the majority of radiation-induced DNA double-strand breaks in
B De Paepe et al.
Journal of clinical pathology, 62(2), 172-176 (2009-02-03)
Mitochondrial diseases display a heterogeneous spectrum of clinical phenotypes and therefore the identification of the underlying gene defect is often a difficult task. To develop an immunohistochemical approach to stain skeletal muscle for the five multi-protein complexes that organise the
Lateral elements inside synaptonemal complex-like polycomplexes in ndt80 mutants of yeast bind DNA.
Bhuiyan, H; Dahlfors, G; Schmekel, K
Genetics null

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