ABS1024
Anti-Angiomotin Antibody
serum, from rabbit
Sinônimo(s):
Angiomotin
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
serum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
human, rat, mouse
técnica(s)
immunocytochemistry: suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... AMOT(154796)
Descrição geral
Angiomotin is a cell surface protein that plays a central role in tight junction maintenance and the uptake of proteins at tight junctions but also appears to regulate endothelial cell response and their migration toward growth factors as well as their response to angiostatin. Thus Angiomotin plays a role in blood vessel formation, cell migration, protein localization, chemotaxis, cellular polarity and many more cell-movement/migration activities. Angiomotin is a component of a multi-protein complex associated at tight junctions that includes ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3 proteins. Angiomotin is expressed in endothelial cells and found in placenta, blood vessels and skeletal muscle tissue, as well as at the leading edge of lamellipodia and cellular processes.
Imunogênio
Epitope: C-terminus
Recombinant protein corresponding to the C-terminus of human Angiomotin.
Aplicação
Research Category
Signaling
Signaling
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
This Anti-Angiomotin Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of Angiomotin.
Western Blotting Analysis: A representative lot detected Angiomotin in MDCK cell lysate (Wells, C. D., et al. (2006). Cell. 125:535-548).
Immunocytochemistry Analysis: A representative lot detected Angiomotin in MDCK cells (Wells, C. D., et al. (2006). Cell. 125:535-548).
Immunocytochemistry Analysis: A representative lot detected Angiomotin in MDCK cells (Wells, C. D., et al. (2006). Cell. 125:535-548).
Qualidade
Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Angiomotin in 10 µg of HEK293 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Angiomotin in 10 µg of HEK293 cell lysate.
Descrição-alvo
~150/80 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~118 kDa and ~73 kDa This high molecular weight observed could be due to high phosphorylation.
forma física
Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified
Armazenamento e estabilidade
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Outras notas
Concentration: Please refer to lot specific datasheet.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Clark D Wells et al.
Cell, 125(3), 535-548 (2006-05-09)
Using functional and proteomic screens of proteins that regulate the Cdc42 GTPase, we have identified a network of protein interactions that center around the Cdc42 RhoGAP Rich1 and organize apical polarity in MDCK epithelial cells. Rich1 binds the scaffolding protein
Ziying Han et al.
The Journal of biological chemistry, 295(25), 8596-8601 (2020-05-10)
The Ebola virus (EBOV) VP40 matrix protein (eVP40) orchestrates assembly and budding of virions in part by hijacking select WW-domain-bearing host proteins via its PPxY late (L)-domain motif. Angiomotin (Amot) is a multifunctional PPxY-containing adaptor protein that regulates angiogenesis, actin
Jacob J Adler et al.
The Journal of biological chemistry, 288(21), 15181-15193 (2013-04-09)
The adaptor protein Amot130 scaffolds components of the Hippo pathway to promote the inhibition of cell growth. This study describes how Amot130 through binding and activating the ubiquitin ligase AIP4/Itch achieves these effects. AIP4 is found to bind and ubiquitinate
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