ABN470

Anti-EPAC1 Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Rap guanine nuclear exchange factor 3, RAPGEF3, cAMPGEF-I, bcm910, cAMP-GEFI, Exchange factor directly activated by cAMP, cAMP-regulated guanine nucleotide exchange factor I, EPAC1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• clone: polyclonal
• application: IHC; WB
• reatividade de espécies: human, rat
• técnica(s): immunohistochemistry: suitable; western blot: suitable

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: human, rat
• técnica(s): immunohistochemistry: suitable; western blot: suitable
• nº de adesão UniProt: O95398
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... RAPGEF3(10411)

Descrição

Descrição geral

Exchange protein directly activated by cAMP 1 (EPAC1) is also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I. EPAC1 is a guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases which are activated through cAMP binding. EPAC1 couples cAMP production to the activation of the Ras family GTPase, Rap. Activation of Rap drives several cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. EPAC1 is part of a signaling complex in which it activates the PI3K gamma complex, which is involved in angiogenesis. EPAC1 may also regulate ion channel formation, intracellular Ca++ signaling, ion transporter activity, and exocytosis. EPAC1 is widely expressed, especially in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord.

Imunogênio

KLH-conjugated linear peptide corresponding to human EPAC1.

Aplicação

Anti-EPAC1 Antibody is a highly specific rabbit polyclonal antibody, that targets Epac & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected EPAC1 in human kidney, thalamus, and cerebellum tissues.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Qualidade

Evaluated by Western Blotting in rat skeletal muscle tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected EPAC1 in 15 µg of rat skeletal muscle tissue lysate.

Descrição-alvo

~103 kDa observed. Uncharacterized bands may appear in some lysate(s).

forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
Rat skeletal muscle tissue lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable