ABN30

Anti-Aromatase Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Cytochrome P450 19A1, Aromatase, CYPXIX, Cytochrome P-450AROM, Estrogen synthase
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: human, pig
• reatividade da espécie (prevista por homologia): chimpanzee (based on 100% sequence homology), porcine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology)
• técnica(s): western blot: suitable
• nº de adesão NCBI: NP_000094
• nº de adesão UniProt: P11511
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... CYP19A1(1588)

Descrição

Descrição geral

Human Aromatase is a membrane-bound enzyme that is localized on the endoplasmic reticulum. While it is found in gonads and adrenal glands where it converts androgens into estrogens in a classical endocrine manner, it is also expressed in various tissues where it regulates local estrogen levels or estrogen/androgen ratios in an intracrine manner. Human Aromatase is known to have two major forms, characterized by one amino acid difference at amino acid position 264 [arginine (264R) and cysteine (264C)]. Abnormal Aromatase hyperactivity is a known cause for Aromatase excess syndrome (AES), which is characterized by excess levels of estrogen, heterosexual precocity in adolescent males and isosexual precocity in adolescent females. On the other hand, Aromatase deficiency (AROD) in Aromatase-deficient (ArKO) mice leads to increased adiposity, an inability to synthesize estrogen, birth defects, and genital-related developmental disorders. It is also reported to play a role in a complex immune-neuro-endocrine network management system in murine cysticercosis.

Especificidade

Other homolgoies: Rat and Mouse (94% sequence homology).

Imunogênio

KLH-conjugated linear peptide corresponding to human Aromatase.

Aplicação

Anti-Aromatase Antibody is an antibody against Aromatase for use in WB.

Research Category
Neuroscience

Research Sub Category
Neurochemistry & Neurotrophins

Western Blot Analysis: 1 µg/mL from a representative lot detected Aromatase in 10 µg of human testis.

Qualidade

Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Aromatase in 10 µg of human placenta tissue lysate. Tween was not used in the Western Blot.

Descrição-alvo

~58 kDa observed. UniProtKB/Swiss-Prot P11511 (CP19A_HUMAN) states a molecular weight of ~58 kDa

forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
Human placenta tissue lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable