ABF29

Anti-NLRP6 (NALP6) Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): NACHT, PYRIN-containing APAF1-like protein 5, LRR and PYD domains-containing protein 6
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: rat, human
• reatividade da espécie (prevista por homologia): rhesus macaque (based on 100% sequence homology)
• técnica(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• nº de adesão NCBI: NP_612202
• nº de adesão UniProt: P59044
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... NLRP6(171389)

Descrição

Descrição geral

NRLP6 (NALP6) (also known as PYRIN-containing Apaf-1-like protein 5 or PYPAF5) belongs to a family of proteins that play a critical role in apoptosis and in inflammatory signaling. Its expression is highly restricted to granulocytes and T-cells. Co-expression of NALP6 with ASC results in synergistic activation of caspase-1-dependent cytokine processing, subsequent NF-kB activation, and downstream recruitment of PYPAF5 to punctate structures in the cytoplasm. Overlapping genes in NALP6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR.

Especificidade

Other homologies: Mouse (93% sequence homology).

This antibody recognizes the NACHT domain of NLRP6 (NALP6).

Imunogênio

Epitope: NACHT domain

Linear peptide corresponding to NACHT domain of human NLRP6 (NALP6).

Aplicação

Anti-NLRP6 (NALP6) Antibody detects level of NLRP6 (NALP6) & has been published & validated for use in WB, IH(P).

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected NLRP6 (NALP6) in epithelial tissue of proximal and distal tubules of human kidney, and in human bone marrow tissue.

Qualidade

Evaluated by Western Blot in rat basophilic leukemia (RBL) cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected NLRP6 (NALP6) in 10 µg of rat basophilic leukemia (RBL) cell lysate.

Descrição-alvo

~99 kDa observed

Nota de análise

Control
Rat basophilic leukemia (RBL) cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable